A Cellular Model Linking Impaired Neuronal Protein Turnover to...
During aging, brain cells accumulate oxidative injury that causes proteins to misfold and become unusable by the cell. The ubiquitin-proteasome system (UPS) plays a helpful role by degrading these...
View ArticleDeep Brain Stimulation Used to Map Therapeutic Targets for Four Brain Disorders
Disrupted interactions between the frontal cortex and basal ganglia lie at the root of numerous disorders characterized by motor, cognitive, and affective dysfunction. Previous research has shown...
View ArticlePatient-reported Autonomic Symptoms Do Not Correlate With Objective Dysfunction
Few centers in the U.S. can provide objective, quantitative testing for the assessment of dysautonomia. Patient-reported symptom questionnaires are often used as a surrogate, even when not validated...
View ArticleImproving Outcomes for Patients With Drug-resistant Epilepsy Through Surgery
About one-third of epilepsy patients have a disease that is considered drug-resistant, meaning they have failed at least two medications. For these individuals, neurosurgical procedures offer the best...
View ArticleCrossing Barriers in CNS Repair: Dr. Fengfeng Bei on Neural Regeneration and...
Fengfeng Bei, PhD, is the principal investigator of the Bei Lab in the Department of Neurosurgery at Brigham and Women’s Hospital and Gene Cell Therapy Insitute investigator at Mass General Brigham....
View ArticleUncovering Hidden Epigenetic Memory in Astrocyte Networks
Astrocytes play important roles in central nervous system (CNS) physiology and pathology for neurological diseases like multiple sclerosis (MS). Until recently, however, little was known about the...
View ArticleStudy Links History of Traumatic Brain Injury to Malignant Brain Tumors
Research led by Mass General Brigham investigators suggests traumatic brain injury (TBI) is a chronic condition that increases the risk of developing a malignant brain tumor. The paper was published in...
View ArticleImproving Surgical Decision-making for Persons Living With Dementia
Limited longitudinal data on outcomes. An inability of the patient to fully participate in the discussion. Vague advance directives with multiple care partners (surrogates). These are among the many...
View ArticleThe First Large Cohort Analysis to Frame Spinal Cord Injury as a Chronic Disease
Traumatic spinal cord injury isn’t just a one-time event but also a chronic condition. Furthermore, people with a history of spinal cord injury are more likely to develop cardiovascular, neurological,...
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Augmented Reality for Advanced Neuronavigation for Arterial Control in Brain...
Arteriovenous malformations (AVMs) are rare and among the most complex cerebrovascular conditions treated in neurosurgery. Although surgical resection can be curative, it carries substantial risk,...
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