Gene Therapy Approach Shows Encouraging Survival Results in Some Patients...
Glioblastoma multiforme (GBM) is one of the most difficult types of cancer to treat, with most patients surviving less than two years after diagnosis. Efforts to develop new therapies based on...
View ArticleNeuroimaging Abnormalities Across Substance Use Disorders Map to a Common...
In 2023, a Brigham and Women’s Hospital team published evidence in Nature Human Behaviour that six psychiatric disorders map to a common brain network. The results suggested neuromodulation targets for...
View ArticleArtificial Intelligence, Machine Learning, and the Future of Neurosurgical Care
Over the past decade, artificial intelligence (AI) and machine learning (ML) have become increasingly prevalent in medicine and healthcare. Brigham and Women’s Hospital neurosurgeon-scientist Timothy...
View ArticleCase Report: Recurrent Intraventricular Hemorrhage in Cerebral Proliferative...
Cerebral proliferative angiopathy (CPA) is a cerebral vascular malformation with distinctive features: large size, absence of dominant feeders or flow-related aneurysms, transdural supply of healthy...
View ArticleAAN 2024: Brigham Neurologists Share Latest Research
This year’s American Academy of Neurology (AAN)’s Annual Meeting will be a hybrid event held in-person in Denver, CO, and virtually on April 13–18, 2024. Faculty from the Neurosciences Center at...
View ArticleProof of Concept: Presenilin-based Gene Therapy Targets Early-onset...
In 2007, researchers from Mass General Brigham proposed in the Proceedings of the National Academy of Sciences that loss of presenilin function underlies memory impairment and neurodegeneration in...
View ArticleExploring How to Enhance Drug Delivery and Efficacy Through Nanoparticles and...
Natalie Artzi, PhD, a principal investigator in the Brigham and Women’s Hospital Department of Medicine, has changed our basic understanding of biomaterials under different environmental and...
View ArticleA Cellular Model Linking Impaired Neuronal Protein Turnover to...
During aging, brain cells accumulate oxidative injury that causes proteins to misfold and become unusable by the cell. The ubiquitin-proteasome system (UPS) plays a helpful role by degrading these...
View ArticleDeep Brain Stimulation Used to Map Therapeutic Targets for Four Brain Disorders
Disrupted interactions between the frontal cortex and basal ganglia lie at the root of numerous disorders characterized by motor, cognitive, and affective dysfunction. Previous research has shown...
View ArticlePatient-reported Autonomic Symptoms Do Not Correlate With Objective Dysfunction
Few centers in the U.S. can provide objective, quantitative testing for the assessment of dysautonomia. Patient-reported symptom questionnaires are often used as a surrogate, even when not validated...
View Article