Use of Multiple Control Tissue Types Recommended for Molecular Studies of...
One of the challenges in studying the genetic basis of cerebrovascular diseases is the difficulty of collecting fresh intracerebral vessels for use as controls. Some experts use the superficial...
View ArticleCase Reports: Novel Congenital Spinal Cord Malformation Not Requiring...
During human embryonic development, the notochord plays an important role in patterning the central nervous system. Abnormalities of the notochord can result in malformations of the spinal cord, which...
View ArticleSocialBit: A Wearable Sensor to Quantify Social Isolation
Social isolation is now understood to rival the effects of cigarette smoking, hypertension, hyperlipidemia, obesity, and physical inactivity as a risk factor for poor health. Researchers at Brigham and...
View ArticleReview: Dural and Extradural Cavernous Venous Malformations
Cavernous-type venous lesions in the central nervous system are conventionally called cavernomas, cavernous angiomas, or cerebral cavernous malformations. Given the typical absence of neoplastic...
View ArticleGene Therapy Approach Shows Encouraging Survival Results in Some Patients...
Glioblastoma multiforme (GBM) is one of the most difficult types of cancer to treat, with most patients surviving less than two years after diagnosis. Efforts to develop new therapies based on...
View ArticleNeuroimaging Abnormalities Across Substance Use Disorders Map to a Common...
In 2023, a Brigham and Women’s Hospital team published evidence in Nature Human Behaviour that six psychiatric disorders map to a common brain network. The results suggested neuromodulation targets for...
View ArticleArtificial Intelligence, Machine Learning, and the Future of Neurosurgical Care
Over the past decade, artificial intelligence (AI) and machine learning (ML) have become increasingly prevalent in medicine and healthcare. Brigham and Women’s Hospital neurosurgeon-scientist Timothy...
View ArticleCase Report: Recurrent Intraventricular Hemorrhage in Cerebral Proliferative...
Cerebral proliferative angiopathy (CPA) is a cerebral vascular malformation with distinctive features: large size, absence of dominant feeders or flow-related aneurysms, transdural supply of healthy...
View ArticleAAN 2024: Brigham Neurologists Share Latest Research
This year’s American Academy of Neurology (AAN)’s Annual Meeting will be a hybrid event held in-person in Denver, CO, and virtually on April 13–18, 2024. Faculty from the Neurosciences Center at...
View ArticleProof of Concept: Presenilin-based Gene Therapy Targets Early-onset...
In 2007, researchers from Mass General Brigham proposed in the Proceedings of the National Academy of Sciences that loss of presenilin function underlies memory impairment and neurodegeneration in...
View ArticleExploring How to Enhance Drug Delivery and Efficacy Through Nanoparticles and...
Natalie Artzi, PhD, a principal investigator in the Brigham and Women’s Hospital Department of Medicine, has changed our basic understanding of biomaterials under different environmental and...
View ArticleA Cellular Model Linking Impaired Neuronal Protein Turnover to...
During aging, brain cells accumulate oxidative injury that causes proteins to misfold and become unusable by the cell. The ubiquitin-proteasome system (UPS) plays a helpful role by degrading these...
View ArticleDeep Brain Stimulation Used to Map Therapeutic Targets for Four Brain Disorders
Disrupted interactions between the frontal cortex and basal ganglia lie at the root of numerous disorders characterized by motor, cognitive, and affective dysfunction. Previous research has shown...
View ArticlePatient-reported Autonomic Symptoms Do Not Correlate With Objective Dysfunction
Few centers in the U.S. can provide objective, quantitative testing for the assessment of dysautonomia. Patient-reported symptom questionnaires are often used as a surrogate, even when not validated...
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